How soon does Opill protect against pregnancy once it's taken?

Opill is a new progestin-only birth control pill (also called the mini-pill), that is available over the counter. That means you don’t need a prescription to get it. Opill is now available on Amazon, Opill’s website, and some drugstores, convenience stores, and grocery stores. A store brand version, simply called “norgestrel daily oral contraceptive,” is also available at Walgreens and CVS.

If you’re not on a hormonal method of birth control, or if you’re on a hormonal method, but you haven’t been using it consistently, when you start taking Opill, it will start being effective at preventing pregnancy after 48 hours. If you have sex during those first 48 hours, you’ll need to use a non-hormonal backup method of birth control, like condoms to prevent pregnancy.