Is there anyone who shouldn’t use Opill?

ribbon Medically reviewed Aug 2026 by Sarah Toler, DNP

Opill is a new progestin-only birth control pill (also called the mini-pill), that is available over the counter. That means you don’t need a prescription to get it. Opill is now available on Amazon, Opill’s website, and some drugstores, convenience stores, and grocery stores. A store brand version, simply called “norgestrel daily oral contraceptive,” is also available at Walgreens and CVS.

Opill is safe for almost everyone who can get pregnant. Opill and store brand norgestrel are safe to take while breastfeeding. You shouldn’t use Opill or any other brand of mini-pill if you currently have breast cancer. Talk to a health care provider before using the mini-pill if you have a history of cancer, have vaginal bleeding and don’t know why, have liver disease or a liver tumor, have a history of stroke, have had bariatric surgery, or have lupus, kidney disease, or heart disease. Also talk to your provider about whether the mini-pill is safe for you if you are taking anticonvulsant medications, like seizure medications.

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Bedsider
Medically Reviewed
Last updated August 2026
Sarah Toler, DNP
Senior Director of Content
Bedsider and Birth control

You deserve access to birth control that fits your body, your life and your plans. Since 2011, Bedsider has been a trusted source of medically reviewed birth control information—covering every method available in the U.S. with guides, real user reviews, side-by-side comparisons, and a clinic search to help you find care near you or online.