Levonorgestrel is one of the longest-studied types of progestin which is the synthetic version of progesterone, a hormone made by the body. And all the scientific evidence to date shows it is super safe. It’s used in hormonal IUDs, some emergency contraception pills, and certain birth control pills.
Prescription EC pill (ella)

What is levonorgestrel?
Will the medications I take make emergency contraceptive pills less effective?
Some enzyme inducer medications and herbal supplements, including a type of antibiotics used to treat tuberculosis; efavirenz, an antiviral used to treat HIV; St. John’s Wort; the seizure medication phenytoin (Dilantin); and the antifungal, griseofulvin, may reduce the effectiveness of emergency contraceptive (EC) pills. So if you are using an enzyme inducer, talk to a health care provider about if EC pills will be effective for you or consider getting an IUD for EC—it’s the most effective option regardless of your other medications.
I took EC for unprotected sex then I had unprotected sex again. Should I take EC again?
Yes. You need to take another dose of emergency contraception (EC) every time you have sex and don’t use another method of birth control.
How is ella different from Plan B One-Step or Next Choice One Dose?
Plan B One-Step, Next Choice One Dose, and other over-the-counter emergency contraception (EC) pills all contain the same medication and work to prevent pregnancy before it starts by delaying ovulation (when your ovary releases an egg). Prescription EC pills ella contain a slightly different medication that also works to prevent pregnancy before it starts by delaying ovulation. That means that no type of EC pills are the same as medication abortion. While all methods of emergency contraception can be used up to five days after unprotected sex, over-the-counter EC is most effective when used within 72 hours (three days), and works even better within 24 hours. But ella is just as effective on the fifth day as it is on the first. How effective EC pills are at preventing pregnancy also depends on how much you weigh. Over-the-counter EC pills are less effective if you weigh 165 pounds or more and prescription EC is less effective if you weigh more than 195 pounds.
Want to learn more?
Does your weight affect how well your birth control works?
For the patch, Xulane or Zafemy, may be less effective if you weigh more than 198 pounds. Twirla, the lower-dose patch option, may be less effective at preventing pregnancy if your BMI is 25 or greater, and it should not be used at all if your BMI is 30 or greater because of decreased effectiveness and a potentially increased risk of blood clots.
When it comes to emergency contraception, over-the counter levonorgestrel-based emergency contraception, like Plan B One-Step, Next Choice One Dose, and others, may not be as effective in people who weigh 165 pounds or more. Prescription EC pill, ella, may not work as well if you weigh 195 pounds or more. Some types of IUD work as EC and they are equally effective no matter how much you weigh.
Your weight will not impact how effective your birth control is for almost all types of birth control. Two exceptions are the patch and emergency contraception.
For the patch, Xulane or Zafemy, may be less effective if you weigh more than 198 pounds. Twirla, the lower-dose patch option, may be less effective at preventing pregnancy if your BMI is 25 or greater, and it should not be used at all if your BMI is 30 or greater because of decreased effectiveness and a potentially increased risk of blood clots.
When it comes to emergency contraception, over-the counter levonorgestrel-based emergency contraception, like Plan B One-Step, Next Choice One Dose, and others, may not be as effective in people who weigh 165 pounds or more. Prescription EC pill, ella, may not work as well if you weigh 195 pounds or more. Some types of IUD work as EC and they are equally effective no matter how much you weigh.
Want to learn more?
How effective is emergency contraception at preventing pregnancy?
If you’re taking over-the-counter EC pills, like Plan B One-Step, Next Choice, or other generics, the sooner you take it after sex, the more effective it is. We repeat: the sooner, the better. You can take it for up to 5 days, but within 3 days is more effective. (You can even get some to have on hand so you have it when you need it.) Over-the-counter EC pills are less effective if you weigh more than 165 pounds, and unfortunately, research shows that taking more than one at a time doesn’t work.
If you’re taking the prescription EC pill, brand name ella, you can take it up to 5 days after sex. Unlike over-the-counter EC pills, it’s as effective on day five as it is on day one. Prescription EC is less effective if you weigh more than 195 pounds.
Getting some types of IUD placed within five days after sex is the most effective method of EC, no matter how much you weigh.
The effectiveness of emergency contraception (EC) depends on what type you use, how soon you take it after having sex, and how much you weigh
If you’re taking over-the-counter EC pills, like Plan B One-Step, Next Choice, or other generics, the sooner you take it after sex, the more effective it is. We repeat: the sooner, the better. You can take it for up to 5 days, but within 3 days is more effective. (You can even get some to have on hand so you have it when you need it.) Over-the-counter EC pills are less effective if you weigh more than 165 pounds, and unfortunately, research shows that taking more than one at a time doesn’t work.
If you’re taking the prescription EC pill, brand name ella, you can take it up to 5 days after sex. Unlike over-the-counter EC pills, it’s as effective on day five as it is on day one. Prescription EC is less effective if you weigh more than 195 pounds.
Getting some types of IUD placed within five days after sex is the most effective method of EC, no matter how much you weigh.

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